etiology of pyoderma gangrenosumoften associated with IBD, rheumatoid conditions(eg. ☆Takayasu arthritis), leukemia, ★myelodysplastic syndrome, and monoclonal gammopathies
usually begins as painless macule/vesicle/pustule/bulla on red/blue base sloughing, leaving a
gangrenous ulcer dermatologyrheumatology国試 Oct 18, 2020, 5:00 AM HirotoShishido
SJS and TENBy convention, SJS denotes <10% of body surface area involvement, >30% is designated as toxic epidermal necrolysis (TEN), and 10%-30% is SJS/TEN overlap. dermatologyUWorld step2CK Oct 5, 2020, 8:39 AM HirotoShishido
① 蕁麻疹の一種であり，真皮下層または皮下組織の限局性浮腫．
② 蕁麻疹と同様に全身に出現するが，特に☆眼瞼，口唇に多い．気道に浮腫を生じた場合には，窒息の危険があるため，☆咽頭内視鏡検査で浮腫の状態を把握する必要がある．
③ 非遺伝性と遺伝性（C1インヒビター欠損症，非常にまれ）の病型がある． dermatology国試過去3年 Sep 21, 2020, 6:35 PM HirotoShishido
mastocytoma=☆urticaria pigmentosa
色素性蕁麻疹
① 皮膚（真皮）や他の臓器で肥満細胞が増殖する疾患．
② 生後1年ごろまでに発症する小児型と，成人に発症する成人型がある．小児型が多い．
③ 反復性の蕁麻疹様発作と，四肢や体幹に褐色斑，褐色調丘疹が多発する．
④ 病変部に機械的刺激を加えると，肥満細胞からのヒスタミン放出により，膨疹を生じる（Darier徴候 dermatology国試過去3年 Sep 21, 2020, 6:32 PM HirotoShishido
Complications of palmoplantar pustulosis手掌や足蹠の膿疱性皮疹をきたす掌蹠膿疱症（PPP：palmoplantar pustulosis）の約10％に多発関節炎，胸鎖関節炎，脊椎炎を伴うことがあり，掌蹠膿疱症性骨関節炎（PAO：palmoplantar pustulotic arthro-osteitis）と呼ぶ．皮膚・骨・関節に症状を認めるSAPHO症候群の一亜型に位置付けられる．SAPHO症候群はSynovitis（滑膜炎），Acne（痤瘡），Pustulosis（膿疱症），Hyperostosis（骨化症），Osteitis（骨炎）の頭文字を取った症候群 この概念はpsoriatic arthritis を含む
histology of acute eczematous dermatitis☆spongiosis
= an accumulation of edema fluid in the intracellular spaces of the epidermis
→ the intracellular bridges become more distinctive in an edematous background, and the epidermis is often described as "spongy" dermatologyUWorld Jun 30, 2020, 7:50 PM HirotoShishido
PictureLichtenberg figures= erythmatous cutaneous marks in a ☆fern-leaf pattern→ pathognomonic of lightning strike
Although lightning injuries are rare, they are associated with a 25% fatality rate, and more than 70% of survivors have long-lasting complications.
Two-thirds of lightning-related deaths occur within the first hour following injury; the most common causes are ☆fatal arrhythmias and respiratory failure cardiologydermatologyUWorld Jun 27, 2020, 4:25 AM HirotoShishido
use lukewarm water rather than hot and neutral or acidic clensers rather than alkaline soaps when bathing+ moisturlize immediate after bathing to prevent excessive skin water loss dermatologyUWorld SIM2 Jun 20, 2020, 5:34 AM HirotoShishido
histology of liposarcomacells with round clear cytoplasmic vaculoles scalloping the nuclear membrane
(lipoblasts)
the most common soft-tissue sarcoma in adults pathologydermatologyUWorld SIM2 Jun 19, 2020, 7:42 PM HirotoShishido
