Drugs with high intrinsic hepatic clearance tend to have ☆high lipophilicity and a ☆high volume of distribution.
・Highly lipophilic drugs tend to be poorly eliminated in the kidney as these agents rapidly cross tubular cell membranes after filtration to reenter the tissues.
・High lipophilicity (lipid solubility) allows the drug to cross cellular barriers more easily and enter hepatocytes. It can then be excreted in the bile or through other methods of elimination.
pharmacology
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Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
