Overt manifestations of diabetes mellitus tend to develop once >90% of beta cells are destroyed.
Although antibodies against islet antigens are detected in a large number of patients, they are thought to play a permissive role in disease pathogenesis; the destruction of beta cells occurs primarily through ☆cell-mediated immunity. Infiltration of islets by inflammatory cells is called insulitis and is more prominent during the early stages of disease.
endocrinology
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