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antimycobacterial drugs isoniazid=↓synthesis of mycolic acid(cell wall)
INH injures Neurons and Hepatocyte←administer with pyridoxine(B6)
SLE

(raft→)rifampin
4R
rifabutin is favored with HIV infection(less CYP stimulation)

(earth→)ethanbutol=inhibit arabinogalactan(cell wall)
optic neuritis,color blindness

pyrazinamide
gout,hepatotoxicity

streptomycin
tinnitus,nephrotoxicity
microbiology pharmacology antibiotics   HirotoShishido

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cephalosporins 4th gens
drugs,bacterias primate→cefeprime

close to 3rd gens
nosocomial infections
febrile neutropenia (postchemotherapy)
microbiology pharmacology antibiotics   HirotoShishido

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cephalosporins 3rd gens
characteristics,drugs,bacterias can cross brain-blood-barrier→meningitis

mechanic→cefixime
taxi→cefotaxime
three head ax→ceftriaxone
dime→ceftazidime

gong→gonorrhea
ceftriaxone→Lyme disease(borreia)
ceftazidime→pseudomonas
microbiology pharmacology antibiotics   HirotoShishido

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cephalosporins 2nd gens
drugs,bacterias falcon→cefaclor
furry coat→cefuroxime
pretzel→cefprozil
fox→cefoxtin
tea cup→cefotetan

HENS PEcK
haemophilus influenzae
enterobacter aerogenes
neisseria spp.
serratia marcescens
microbiology pharmacology antibiotics   HirotoShishido

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cephalosporins 1st gens
drugs,bacterias violin→cephazolin
Alex→cephalexin

PEcK,prophylaxis before surgery(prevents S aureus wound infections)

gram+,proteus mirabilis,e.coli,klebsiella→UTI
microbiology pharmacology antibiotics   HirotoShishido

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respiratory fluoroquinolones young flock of seagulls

levi's→levofloxacin
moxie→moxifloxacin
space jam→gemifloxacin
pharmacology microbiology antibiotics   HirotoShishido

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antimetabolites (inhibit DNA synthesis)

sulfonamides→sulfamethoxazole,sulfisoxazole,sulfadiazine

trimethoprim
microbiology pharmacology antibiotics   HirotoShishido

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glycopeptides
drugs,adverse effects ①VAN(MOUSe is printed)→VANcoMYCIn
television→TELavancin
COP(police)→teiCOPlanin

MRSA(Mars rover), C difficile(closet)

generally tolerable but NOT travel free(in dress)
Nephrotoxicity, Ototoxicity, Thrombophlebitis(血栓性静脈炎),diffuse flushing(red man syndrome)
DRESS synd(drug reaction with eosinophilia and systemic symptoms synd)

②(Basilisk→)bacitracin
gram+(narrow spectrum, S aureus,S epidermis, S pyogens)
topical use only ☆because of its harsh nephrotoxic effects
microbiology pharmacology antibiotics   HirotoShishido

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tetracyclines
drugs,clinical use,adverse effects four tires→tetracycline
minotaur→minocycline
doctor→doxycycline
tiger→tigercycline

acne, community acquired pneumonia
<intracellular>
①(hiker→)walking pneumonia,②(giant clam→)chlamydia,③rabit fever(francisella,野兎病),④Rocky mountain spotted fever(rickettsia)

(aiming at the doctor→)doxycycline is used
⑤(brunette wig→)coxiella barnetii(Q fever),
⑥Lyme disease(Borrelia)
doxycycline→prevent malaria
tigercycline and doxycycline→MRSA

photosensitivity, built in teeth and bones,tinnitus etc
microbiology pharmacology antibiotics   HirotoShishido

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broad spectrum penicillins
drugs,clinical use (mocking bird→)amoxicillin,(a magpieカササギ→)ampicillin
amOxicillin has greater Oral bioavailability

antipseudomonal→ (pepper→)piperacillin, (tiger→)ticarcillin


both can HHELP SMithS kill enterococci

H influenzae,H pylori,E coli,Listeria monocytogenes,Proteus mirabilis,Salmonella,Moraxella catarrhalis,Shigella,enterococci
microbiology pharmacology antibiotics   HirotoShishido

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penicillinase resistant penicilin
drugs, clinical use very narrow spectrum

(OX→)OXacillin
(NApping Fox→)NAFcillin
(MaTH textbook→)MeTHicillin
(CLOCK→)CLOXacillin
(DIgital CLOCK→)DICLOXacillin

S aureus(not for MRSA), S epidermidis
microbiology pharmacology antibiotics   HirotoShishido

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