PE
platelet endothelial cell adhesion molecule =CD31
☆DiaPEdesis (transmigration) pathologyUWorld Jun 26, 2020, 4:01 AM HirotoShishido
HPV carcinogenesisHPV viral protein E6 binds to ☆p53, a tumor suppressor protein that normally inhibits the proliferation of cells with genetic abnormalities. Ubiquitination of the E6-p53 complex induces degradation of p53, leading to unregulated cellular growth.
HPV viral protein E7 binds to retinoblastoma(Rb) protein, which results in the displacement of E2F (a transcription factor that induces cell cycle activation), promoting unregulated DNA replication and cyclin-mediated cell cycling. microbiologypathologyfree120 Jun 18, 2020, 8:51 AM HirotoShishido
histology of liposarcomacells with round clear cytoplasmic vaculoles scalloping the nuclear membrane
(lipoblasts)
the most common soft-tissue sarcoma in adults pathologydermatologyUWorld SIM2 Jun 19, 2020, 10:42 PM HirotoShishido
vemurafenib= BRAF kinase inhibitor is used for melanoma with BRAF V600E poistive(seen in 40-60% of patients with melanoma) pathologyoncologyUWorld Jun 18, 2019, 8:46 AM HirotoShishido
