BPH symptoms(start when prostatic urethra obstructed)
dribbling(weak stream of urine)
dysuria(pain during urination)
have to strain when urinating
hesitensy(trouble initiating urination)
nocturia reproductiveurology HirotoShishido
benign prostatic hyperplasia(BPH) pathogenesis(5α-redactase convert testosterone into dihydrotestosterone,DHT)
after 30yo,testosterone production decline by 1% every year
meanwhile,5α-redactase increase with age
which cell does secrete inhibin B, androgen binding protein(ABP), and Müllerian inhibitory factor(MIF) in male reproductive system・Sertoli cells
inhibin B which inhibit FSH
ABP allows testosterone to cross blood-testis barrier
(☆if dysfunctioning, low concentration of testosterone in the seminiferous tubule and normal circulating teststerone level can be seen(as long as hypothalamus-pituitary-gonad axis are normally functioning)
MIF that suppress development of paramesonephric ducts
