"musculoskeletal" Post in this tag
chronic osteomyelitis
sequestrum(腐骨) and involucrum(骨柩=new bone) is formed
sequestrum has to be removed by surgery
musculoskeletal
HirotoShishido
recombinant analog of the parathyroid hormone
①effects ②side effects ③contraindication
teriparatide
(given subcutaneously once/day)
①stimulates osteoblasts→reduces apoptosis→build more bones than what is being lost
②(transient)hypercalcemia
increased risk of developing osteosarcoma
③avoided w/ paget's disease of bone
musculoskeletal
pharmacology
HirotoShishido
parathyroid hormone, calcitonin effects
PTH low conc→stimulates osteoblast→promotes bone formation
PTH high conc→increase bone resorption
calcitonin→supress osteoclasts→decrease bone resorption
pharmacology
musculoskeletal
HirotoShishido
bisphosphonate side effects
oral→upper GI side effects(esophagitis,gastric irritation)→taken w/ plenty of water+stay upright for at least 30mins
intravenous→osteonecrosis of the jaw
musculoskeletal
pharmacology
HirotoShishido
①simple, non-nitrogenous bisphosphonates
②potent, nitrogenous bisphosphonates
①ATP is built up in osteoclast→apoptosis→less bone resorption
e.g.etidronate
②inhibit osteoclast's mevalonate passway→disrupts synthesis of cholesterol→osteoclast becomes nonfunctional
e.g.☆alendronate
pharmacology
musculoskeletal
HirotoShishido
osteogenesis imperfecta symptoms
BITE
bones=multiple fracture
I(eye)=blue sclerae
teeth=dental imperfections
ear=hearing loss
musculoskeletal
HirotoShishido
diagnosis of paget's disease of bone
increased level of alkaline phosphatase
lytic lesion(lytic phase),thickened bone cortices on X-ray
bone biopsy (to exclude malignancy)
musculoskeletal
endocrinology
HirotoShishido
DDH on X-ray,male-to-female ratio,treatment
(developmental dysplasia of the hip)
③Shenton line and ④Calvé line have to be continuous and smooth in a normal newborn
1:7
Pavlik harness(Riemenbügel装置)
→traction therapy
→surgery
musculoskeletal
pediatrics
HirotoShishido
radial artery,ulnar artery location
radial artery→medial side of brachioradialis,lateral side of flexor carpi radialis
ulnar artery→V(?)AN from lateral
musculoskeletal
HirotoShishido
腸腰筋(大腰筋、腸骨筋)、大殿筋、梨状筋、薄筋、上双子筋
iliopsoas(psoas major,iliacus),
gluteus maximus,
piriformis,gracilis,
gemellus superior
musculoskeletal
HirotoShishido
neck pain <orthopedics>
neck sprain,
post-traumatic cervical syndrom(PTCS)=whiplash(むちうち),
servical spondylosis→①cervical spondylotic myelopathy②cervical spondylotic radiculopathy(radikjʊlapəθi)
discitis,spondylitis,spinal epidural abscess,spinal epidural hematoma
musculoskeletal
HirotoShishido
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