oligoarticular(less than 5 joints)
polyarticular(more than 5 joints)
spondyloarthritis
distal interphalangeal predominant (affects joints at the end of the fingers and toes→dactylitis)
arthritis multilans
NSAIDs,(for more severe)sulfasalazine,methotrexate(disease modifying anti-rheumatic drugs,DMARDs)
①when does it appear ②which types of HLA ③other diseases associated with(②) ④what does (②)gene code for①2-3weeks after sexually transmitted infection or gastroenteritis
②HLA-B27
③psoriasis,ankylosing spondylitis
④MHC1 musculoskeletalrheumatology HirotoShishido
DR2 DRiving 2 MULTIPLE(MS) HAY(hay fever) PASTURES(goodpasture) will cause NARCOLEPSY
DR2+3 SLE
DR3+4 DM type Ⅰ
DR4 rheumatoid arthritis
DR3+5 HASHIMOTO is an ODD DoctoR(3,5)
DR8 primary biliary cholangitis immunologyrheumatology HirotoShishido
Systemic juvenile idiopathic arthritis=still’s disease
onset at any age, M=F
•once or twice daily fever spikes(>38.5oC)≥ 2d/wk with temperaturere turning below baseline; children
usually acutely unwell during fever episodes
• extra-articular features: erythematous “salmon-coloured” maculopapular rash, lymphadenopathy,
☆hepatosplenomegaly, leukocytosis, thrombocytosis, anemia, serositis
•arthritis may occur weeks to months later rheumatology国試過去3回 HirotoShishido
treatment for organ threatning disease in SLEIV cyclophosphamide for serious organ involvement (e.g. cerebritis or lupus nephritis) for clinical features of lupus nephritis rheumatology過去3回国試 HirotoShishido
triggers associated w/ lupusgenetic susceptibility,UV radiation,cigarette smoking,bacteria or virus,estrogen,medications("DILE" sulfa drugs, ★hydralazine, isoniazid, methyldopa, minocycline, procainamide, phenytoin, and etanercept (SHIMMPP-E))
these medications are ☆metabolized via phase Ⅱ acetylation in the liver
where does it hurt in the patient with polymyalgia rheumaticapain and (morning)stiffness in proximal muscles(shoulders, hips) rheumatology HirotoShishido
