Evans syndrome
Which autoimmune disease is this associated with?warm autoimmune hemolytic anemia(warm weather is Great→IgG)+immune thrombocytopenic purpura
Increased erythropoiesis (e.g., secondary to hemolysis, blood loss, ☆vitamine B12 supplementation(bigins rising within 3,4 days, and peaks at around 1 week))
when does therapeutic efficacy of warfarin take placeTherapeutic efficacy is delayed until ☆preexisting clotting factors in the plasma are consumed.
Although INR tends to slowly increase in the first few days of administration due to the short half-life of factor VII (4-6 hours), full therapeutic effect does not typically occur for 3 days due to the long half-life of factor II. hematologypharmacologyUWorld HirotoShishido
change in PTH for the patients with multiple myelomaosteolytic cytokines→
liberate calcium from bone→
hypercalcemia→
inhibits the release of PTH from parathyroid cells→
①increase urinary calcium excretion(☆hypercalciuria)
②reduce renal 1-alfa-hydroxylase→☆low 1,25 dihydroxyvitamine D endocrinologyhematologyUWorld HirotoShishido
heparin-induced trombocytopenia and thrombosis(HITT)
onset, mechanism of aggregation+thrombocytopenia5-10days following exposure to heparin products
the generation of IgG antibodies to ☆heparin and platelet factor 4(PF4) → Fc component of the IgG than binds to additional platelets→ widespread platelet activation
