DR2 DRiving 2 MULTIPLE(MS) HAY(hay fever) PASTURES(goodpasture) will cause NARCOLEPSY
DR2+3 SLE
DR3+4 DM type Ⅰ
DR4 rheumatoid arthritis
DR3+5 HASHIMOTO is an ODD DoctoR(3,5)
DR8 primary biliary cholangitis immunologyrheumatology Apr 23, 2019, 10:25 AM HirotoShishido
hyperacute transplant rejection
pathogenesis(occurs within minutes)
pre-existing recipient antibodies react to donor antigen(type Ⅱ hypersensitivity reaction) immunology Aug 2, 2019, 7:56 AM HirotoShishido
TAP protein
functionTAP(transporter associated with antigen processing) protein transports some of the peptide fragments degraded by proteasome into the endoplasmic reticucum and load onto ☆MHC class Ⅰ molecules
genetic mutation affecting MHC claps Ⅰ polypeptide complex expression(bare lymphocyte syndrome type Ⅰ)
→ulcerative glanulomatous skin lesions and frequent respiratory infeltions ☆despite normal lymphocyte and immunoglobulin levels immunologyUWorld Feb 13, 2020, 9:50 AM HirotoShishido
how does natural killer cells workuse ☆perforin and granzymes to induce apoptosis of virally infected cells and tumor cells immunology Dec 30, 2019, 12:39 AM HirotoShishido
staphylococcal toxic shock syndrome(TSS)
pathophysiology, etiology, symptomsTSST-1(superantigen) binds to ☆MHCⅡ and T-cell receptor, resulting in polyclonal T-cell activation
