neonatal intraventricular hemorrhage
sourse of bleeding, predisposing factor☆germinal matrix (sources of neurons and glial cells during brain development)
IVH almost always manifest within the first 5 postnatal age in patients born before 32 weeks gestation and/or with birth weight<1500 g neurologypediatricsUWorld HirotoShishido
congenital torticollistypically develops by 2 to 4 weeks of age
It is most commonly caused by birth trauma (eg, breech delivery) or ☆malposition of the head in utero (eg, due to fetal macrosomia or oligohydramnios),both of which can result in sternocleidomastoid muscle(SCM) injury and fibrosis. OBGYpediatricsUWorld HirotoShishido
Pierre Robin sequencemicrognathia, glossoptosis, cleft palate, airway obstruction(☆improve with prone position)
pharmacokinetic difference between neonatal patients and adults↑Proportion of body water
Blood-brain barrier immaturity
→☆↑Distribution of water-soluble drugs(eg aminoglycosides, vancomycin) may necessitate higher mg/kg dose, ↑CNS toxicity
