the difference of mechanism between paclitaxel and vinca alkaloidspaclitaxel(TAXanes)→ ☆hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down(anaphase cannot occur)
(TAX STABILIZE the society)
vinca alkaloids→ bind β-tubulin and ☆inhibit microtubule polymerization →prevent mitotic spindle formation(M phase arrest) pharmacologyoncology Dec 25, 2019, 1:25 AM HirotoShishido
1st line for recurrent status epilepticus prophylaxis(acute→benzodiazepines)
The diagnosis can be confirmed with serologic testing for B henselae. Although generally self-limited, empiric antibiotic therapy with ☆azithromycin may prevent dissemination of infection to the liver, spleen, or nervous system.
systematic approach to stepping up medications for asthmaSABA(short acting albuterol inhaler), then low-dose ICS(inhaled corticosteroids), then moderate-dose ICS, then high-dose ICS, then LABA(long), and lastly oral corticosteroids.
adverse effects of interferon☆neutropenias, neuropsychiatric symptoms(eg. depression), autoimmune disorders, and ischemic symptoms. pharmacology Jan 4, 2020, 2:28 AM HirotoShishido
used as an antitussive in adult and pediatric patients with a persistent cough after ruling out other potential pathologies (COPD, asthma, allergies, sinusitis) pharmacologyrespiratory Dec 14, 2019, 3:18 AM HirotoShishido
OCTs contraindications☆smokers>35yo(↑risk of cardiovascular event)
