"NBME" Post in this tag
common type of melanoma in Asians and Africans
acral lentiginous(末端黒子型)
on the ☆palms and soles
dermatology
NBME
Apr 5, 2020, 3:04 AM
HirotoShishido
renal tubular defect
order
Fanconi's BaGeLS
Fanconi syndrome→ PCT→☆phosphaturia
Bartter syndrome→ thick ascending limb
Gitelman syndrome→ DCT
Liddle syndrome→ collecting duct
SAME(syndrome of apparent mineralcorticoid excess)
renal
NBME
Apr 4, 2020, 9:23 PM
HirotoShishido
the most effective agents for lowering LDL
statin, ezetimibe, PCSK9 inhibitors(alirocumab)
☆statin lncrease synthesis of LDL receptors→↑LDL recycle
+inhibit conversion of hydroxymethylglutaryl CoA to mevalonate
pharmacology
endocrinology
NBME
Dec 10, 2019, 6:03 AM
HirotoShishido
crystals of gout and pseudogout
gout→ ☆monosodium phosphate
needle shaped, -birefringent
pseudogout→ calcium pyrophosphate dihydrate
☆rhomboid, weakly +birefringent
musculoskeletal
NBME
free120
Apr 5, 2020, 1:48 AM
HirotoShishido
lamin, laminin
lamin= fibrous protein that form the two dimensional network on the inner surface of the nuclear membrane
laminin= ECM glycoprotein, major component of the basal lamina
biology
pathology
NBME
Apr 5, 2020, 4:18 AM
HirotoShishido
blindness caused by nematodes
onchocerca volvulus(FLY guy→transmitte by ☆black fly) →river blindness, black skin nodules
ivermectin
toxocara canis(wolfman→イヌ回虫)
bendazole
microbiology
NBME
Sep 2, 2019, 9:38 AM
HirotoShishido
NNRTIs
drugs, side effects
(nonnucleoside reverse transcriptase inhibitor)
nevirapine, delavirdine, ☆efavirenz
point mutation in the reverse transcriptase region of HIV pol gene against one NNRTI can confer ☆cross-resistance against other NNRTI
☆hepatotoxicity, rash
microbiology
UWorld SIM2
NBME
Apr 5, 2020, 3:15 AM
HirotoShishido
trichinella spiralis
symptoms, diagnosis
(旋毛虫)
Typical signs and symptoms include diarrhea and abdominal pain, followed 2 or more weeks later by myalgias, ☆conjunctival hemorrhages, ☆★periorbital edema, and eosinophilia
☆muscle biopsy
infectious disease
NBME
UWorld step2CK
Dec 3, 2019, 12:13 AM
HirotoShishido
urgency incontinence, atonic bladder
medication
urgency→
oxybutynin(muscarinic antagonist M3)
mirabegron(sympathomimetics β3)
atonic(non obstructive urinary retension)→
bethanecol(muscarinic agonist)
pharmacology
UWorld
NBME
Mar 6, 2020, 7:10 AM
HirotoShishido
leukocyte adhesion deficiency type1
defect, presentation
defect in LFA-1 integrin(☆CD18) protein on phagocytosis
→impaired ☆migration and chemotaxis
recurrent skin and mucosal bacterial infections(eg. omphalitis, ★periodontitis)
delayed (>30days) separation of umbilical cord, absent pus, ☆persistent leukocytosis due to leukocyte not being able to migrate out of the blood vessels
immunology
NBME
UWorld step2CK
Nov 24, 2019, 6:28 AM
HirotoShishido