diffrentiate between folate and vitamin B12 deficiency↑ homocysteine in both
☆↑ methylmalonic acid only in cobalamin deficiency(cobalamin=cofacter for methylmalonyl CoA mutase)
(methylmalonyl CoA is converted to succinyl CoA with the cofactor vitamin B12. If there is not enough vitamin B12 present, methylmalonyl CoA is alternatively converted to methylmalonic acid) hematologyUWorld Jun 13, 2019, 10:49 PM HirotoShishido
Can be inherited or 2° to strong immunologic activation (eg, after ☆EBV infection, malignancy). Bone marrow biopsy shows macrophages phagocytosing marrow elements. hematology国試過去3回 Nov 21, 2019, 7:07 PM HirotoShishido
warm autoimmune hemolytic anemia(AIHA)
associated diseaseSLE, CLL
(and with certain drugs (eg)α-methyldopa) hematology Jan 1, 2020, 9:12 PM HirotoShishido
localized, single group of nodes are affected, contiguous spreadHodgkin lymphoma
Hb precipitation→subsequent phagocytic damage to RBC membrane→bite cells hematology Dec 18, 2019, 11:45 PM HirotoShishido
the difference between
extranodal NK/T-cell lymphoma, nasal type and plasmablastic lymphomaNK/T→ CD56
plasmablastic→ CD138 hematology Nov 20, 2019, 6:54 PM HirotoShishido
to which microorganisms are the patients with sickel cell anemia susceptible?encapsulated organisms
(☆salmonella)→osteomyelitis hematology Nov 20, 2019, 3:29 AM HirotoShishido
sources of allogeneic hematopoietic stem cell transplantation(HSCT)BMT(bone marrow transplantation)
PBSCT(peripheral blood stem cell transplantation)
CBT(cord blood transplantation) hematology Nov 19, 2019, 2:28 AM HirotoShishido
allogeneic transplantation(同種移植)
→acute myelogenous leukemia(AML),
chronic myelogenous leukemia(CML)(AP accelerated phase, BP blast phase), myelodysplastic syndromes(MDS), aplastic anemia(AA) hematology Nov 19, 2019, 2:24 AM HirotoShishido
Trousseu syndromeepisodes of vessel inflammation due to blood clot (thrombophlebitis) which are recurrent or appearing in different locations over time
