mecA geneencodes for penicillin binding protein (PBP) 2a
unlike other PBP, PBP 2a has ☆low affinity for beta-lactams and continues to cross link peptidoglycan in the presence of oxacillin, methicillin, ☆cephalosporins, and other beta lactam medications microbiologypharmacologyUWorld Jul 10, 2020, 5:07 AM HirotoShishido
N-acetylcysteineNAC
Mucolytic - liquifies mucus in chronic bronchopulmonary diseases (eg, COPD, CF) by disrupting disulfide bonds. Also used as an antidote for acetaminophen overdose. respiratorypharmacology Jul 10, 2020, 1:13 AM HirotoShishido
diagnosis/ causes of rhabdomyolysis☆Positive blood on urine dipstick (a reaction that detects the heme pigment in both hemoglobin and myoglobin) in the absence of red blood cells on microscopic urinalysis suggests myoglobinuria.
what dirupt the BBB (blood-brain barrier) and increase permeability
of medicationshyperosmolar agents (eg mannitol) neurologypharmacology Jul 6, 2020, 3:57 AM HirotoShishido
treatment for pseudogoutacute: NSAIDs, colchicine(same as gout) ☆> glucocorticoids
acidic environment for lipaselipase is inactivated by the acidic environment of the stomach
→ PPI use ☆increases lipase activity , enhancing fat absorption in patients dependent on pancreatrc enzyme replacement therapy gastrointestinalpharmacologyUWorld Jul 5, 2020, 7:01 AM HirotoShishido
drugs which has been shown to improve long-term survival in patients with HF due to left ventricular systolic dysfunctionβ-blocker(Bisoprolol, ☆Carvedilol, Metoprolol (β-blockers Curb Mortality)),
ACE inhibitors, ARB, aldosterone antagonists cardiologypharmacologyUWorld Jul 2, 2020, 10:07 AM HirotoShishido
oral rehydration for children with watery diarrheahypotonic, equimolar concentrations of ☆sodium and glucose solution
sodium creates osmotic gradient by active cotransportation, increasing water reabsorption from GI lumen into lamina propria and ultimately the bloodstream gastrointestinalpharmacologyUWorld Jun 30, 2020, 3:17 AM HirotoShishido
